Correlation between Fecal Concentrations of Ciprofloxacin and Fecal Counts of Resistant Enterobacteriaceae in Piglets Treated with Ciprofloxacin: toward New Means To Control the Spread of Resistance? | Zendy

Thu Thuy Nguyen | Zendy; Élisabeth Chachaty | Zendy; Clarisse Huy | Zendy; Carole Cambier | Zendy; Jean de Gunzburg | Zendy; France Mentré | Zendy; Antoine Andremont | Zendy

Open Access

Correlation between Fecal Concentrations of Ciprofloxacin and Fecal Counts of Resistant Enterobacteriaceae in Piglets Treated with Ciprofloxacin: toward New Means To Control the Spread of Resistance?

Author(s) -

Thu Thuy Nguyen,

Élisabeth Chachaty,

Clarisse Huy,

Carole Cambier,

Jean de Gunzburg,

France Mentré,

Antoine Andremont

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.06402-11

Subject(s) - ciprofloxacin , feces , enterobacteriaceae , antibacterial agent , biology , antibiotics , microbiology and biotechnology , zoology , veterinary medicine , medicine , escherichia coli , biochemistry , gene

We assessed in a piglet model the relationship between fecal ciprofloxacin concentrations and ciprofloxacin-resistant Enterobacteriaceae counts. Twenty-nine piglets were orally treated with placebo or with 1.5 or 15 mg ciprofloxacin/kg of body weight/day from day 1 (D1) to D5. Areas under the curve (AUC) of concentrations increased sharply with dose and correlated positively with AUC of resistant bacteria log counts between D1 and D9. Removing residual colonic quinolones could help to control the emergence of resistance in fecal flora.

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