The Spiroindolone Drug Candidate NITD609 Potently Inhibits Gametocytogenesis and Blocks Plasmodium falciparum Transmission to Anopheles Mosquito Vector | Zendy

J. C. van Pelt-Koops | Zendy; Helmi Pett | Zendy; Wouter Graumans | Zendy; M. van der Vegte-Bolmer | Zendy; Geert Jan van Gemert | Zendy; Matthias Rottmann | Zendy; Bryan K. S. Yeung | Zendy; Thierry T. Diagana | Zendy; Robert W. Sauerwein | Zendy

Open Access

The Spiroindolone Drug Candidate NITD609 Potently Inhibits Gametocytogenesis and Blocks Plasmodium falciparum Transmission to Anopheles Mosquito Vector

Author(s) -

J. C. van Pelt-Koops,

Helmi Pett,

Wouter Graumans,

M. van der Vegte-Bolmer,

Geert Jan van Gemert,

Matthias Rottmann,

Bryan K. S. Yeung,

Thierry T. Diagana,

Robert W. Sauerwein

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.06377-11

Subject(s) - anopheles stephensi , gametocyte , plasmodium falciparum , anopheles , malaria , biology , vector (molecular biology) , primaquine , transmission (telecommunications) , lumefantrine , virology , artemether/lumefantrine , mefloquine , artemether , drug , artemisinin , pharmacology , immunology , aedes aegypti , chloroquine , genetics , botany , electrical engineering , engineering , larva , gene , recombinant dna

The global malaria agenda has undergone a reorientation from control of clinical cases to entirely eradicating malaria. For that purpose, a key objective is blocking transmission of malaria parasites from humans to mosquito vectors. The new antimalarial drug candidate NITD609 was evaluated for its transmission-reducing potential and compared to a few established antimalarials (lumefantrine, artemether, primaquine), using a suite of in vitro assays. By the use of a microscopic readout, NITD609 was found to inhibit the early and late development of Plasmodium falciparum gametocytes in vitro in a dose-dependent fashion over a range of 5 to 500 nM. In addition, using the standard membrane feeding assay, NITD609 was also found to be a very effective drug in reducing transmission to the Anopheles stephensi mosquito vector. Collectively, our data suggest a strong transmission-reducing effect of NITD609 acting against different P. falciparum transmission stages.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research