Chromosomal Mutations Responsible for Fluoroquinolone Resistance in Ureaplasma Species in the United States | Zendy

Li Xiao | Zendy; Donna M. Crabb | Zendy; Lynn B. Duffy | Zendy; Vanya Paralanov | Zendy; John I. Glass | Zendy; Ken B. Waites | Zendy

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Chromosomal Mutations Responsible for Fluoroquinolone Resistance in Ureaplasma Species in the United States

Author(s) -

Li Xiao,

Donna M. Crabb,

Lynn B. Duffy,

Vanya Paralanov,

John I. Glass,

Ken B. Waites

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.06342-11

Subject(s) - biology , plasmid , ureaplasma , microbiology and biotechnology , gene , mutation , levofloxacin , genetics , drug resistance , virology , antibiotics , mycoplasma

We sequenced the full lengths of the gyrA, gyrB, parC, and parE genes in 13 fluoroquinolone-resistant Ureaplasma isolates (levofloxacin MICs, 4 to 32 μg/ml) and 10 susceptible isolates (MICs ≤ 2 μg/ml). Mutations were detected in all resistant isolates but in none of the susceptible isolates. The most prevalent mutation was the S83L substitution in the ParC protein. No plasmid-mediated fluoroquinolone resistance genes were detected.

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