Comparison of the Clinical Characteristics and Outcomes Associated with Vancomycin-Resistant Enterococcus faecalis and Vancomycin-Resistant E. faecium Bacteremia | Zendy

Kayoko Hayakawa | Zendy; Dror Marchaim | Zendy; Emily T. Martin | Zendy; Namita Tiwari | Zendy; Adnan Yousuf | Zendy; Bharath Sunkara | Zendy; Harish Pulluru | Zendy; Harikrishna Kotra | Zendy; Asma Hasan | Zendy; Suchitha Bheemreddy | Zendy; Puja Sheth | Zendy; Dae-Won Lee | Zendy; Srinivasa Kamatam | Zendy; Pradeep Bathina | Zendy; Priyanka Nanjireddy | Zendy; Indu K. Chalana | Zendy; Satyam Patel | Zendy; Sarwan Kumar | Zendy; Amit Vahia | Zendy; Kimberly Ku | Zendy; Victoria J. Yee | Zendy; Jessie Swan | Zendy; Jason M. Pogue | Zendy; Paul Lephart | Zendy; Michael J. Rybak | Zendy; Keith S. Kaye | Zendy

Open Access

Comparison of the Clinical Characteristics and Outcomes Associated with Vancomycin-Resistant Enterococcus faecalis and Vancomycin-Resistant E. faecium Bacteremia

Author(s) -

Kayoko Hayakawa,

Dror Marchaim,

Emily T. Martin,

Namita Tiwari,

Adnan Yousuf,

Bharath Sunkara,

Harish Pulluru,

Harikrishna Kotra,

Asma Hasan,

Suchitha Bheemreddy,

Puja Sheth,

Dae-Won Lee,

Srinivasa Kamatam,

Pradeep Bathina,

Priyanka Nanjireddy,

Indu K. Chalana,

Satyam Patel,

Sarwan Kumar,

Amit Vahia,

Kimberly Ku,

Victoria J. Yee,

Jessie Swan,

Jason M. Pogue,

Paul Lephart,

Michael J. Rybak,

Keith S. Kaye

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.06299-11

Subject(s) - bacteremia , enterococcus faecium , enterococcus faecalis , medicine , vancomycin , vancomycin resistant enterococcus , microbiology and biotechnology , antibiotics , bacteria , biology , staphylococcus aureus , genetics

In published studies, cohorts of patients with bacteremia due to vancomycin-resistantEnterococcus (VRE) have predominantly been infected withEnterococcus faecium . Little is known about the epidemiology and outcomes associated with bacteremia due to VREnterococcus faecalis . A retrospective study of isolates obtained from January 2008 to October 2010 was conducted at Detroit Medical Center (DMC). Unique patients with blood cultures positive for VRE were reviewed. Outcomes were analyzed using logistic regression. During the study period, 105 cases of bacteremia due to VRE. faecalis and 197 cases of bacteremia due to VRE. faecium were identified. The mean age in the study cohort was 61.5 ± 15 years; 162 subjects (53.6%) were male. After controlling for a propensity score, bacteremia due to VRE. faecalis was associated with >2-fold-lower in-hospital mortality than bacteremia due to VRE. faecium . Interestingly, bacteremia due to VRE. faecalis was associated with longer hospital stay after VRE isolation, although total length of stay was similar for groups with VRE. faecalis and VRE. faecium . Bacteremia due to VRE. faecalis was associated with a >2-fold-lower risk for mortality than bacteremia due to VRE. faecium , possibly due to the availability of β-lactam therapeutics for treatment of VRE. faecalis .

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research