In Vitro Activity of TD-1792, a Multivalent Glycopeptide-Cephalosporin Antibiotic, against 377 Strains of Anaerobic Bacteria and 34 Strains of Corynebacterium Species | Zendy

Kerin L. Tyrrell | Zendy; Diane M. Citron | Zendy; Yumi A. Warren | Zendy; Ellie J. C. Goldstein | Zendy

Open Access

In Vitro Activity of TD-1792, a Multivalent Glycopeptide-Cephalosporin Antibiotic, against 377 Strains of Anaerobic Bacteria and 34 Strains of Corynebacterium Species

Author(s) -

Kerin L. Tyrrell,

Diane M. Citron,

Yumi A. Warren,

Ellie J. C. Goldstein

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.06274-11

Subject(s) - microbiology and biotechnology , daptomycin , glycopeptide , cephalosporin , vancomycin , antibiotics , biology , bacteria , anaerobic bacteria , corynebacterium , staphylococcus aureus , genetics

TD-1792 is a multivalent glycopeptide-cephalosporin heterodimer antibiotic with potent activity against Gram-positive bacteria. We tested TD-1792 against 377 anaerobes and 34 strains of Corynebacterium species. Against nearly all Gram-positive strains, TD-1792 had an MIC₉₀ of 0.25 μg/ml and was typically 3 to 7 dilutions more active than vancomycin and daptomycin.

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