rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains | Zendy

Patrick Beckert | Zendy; Doris Hillemann | Zendy; Thomas A. Kohl | Zendy; Jörn Kalinowski | Zendy; Elvira Richter | Zendy; Stefan Niemann | Zendy; Silke Feuerriegel | Zendy

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rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains

Author(s) -

Patrick Beckert,

Doris Hillemann,

Thomas A. Kohl,

Jörn Kalinowski,

Elvira Richter,

Stefan Niemann,

Silke Feuerriegel

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.06227-11

Subject(s) - linezolid , mycobacterium tuberculosis , microbiology and biotechnology , biology , mutation , 23s ribosomal rna , mutant , tuberculosis , strain (injury) , mycobacterium , ribosomal rna , virology , genetics , bacteria , medicine , rna , gene , staphylococcus aureus , ribosome , pathology , vancomycin , anatomy

The ribosomal L3 protein was identified as a novel target in linezolid (LZD)-resistantMycobacterium tuberculosis strains. Next-generation sequencing confirmedrplC T460C as the sole mutation in an LZD-resistantM. tuberculosis H37Rv strain selectedin vitro . Sequencing analysis revealed therplC T460C mutation in eight further LZD-resistant isolates (threein vitro -selected mutants and five patient isolates, including isolates from three different patients that developed LZD resistance during treatment) but in none of the susceptible control strains (n = 84).

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