Plasma Concentrations of Posaconazole Administered via Nasogastric Tube in Patients in a Surgical Intensive Care Unit | Zendy

Dominic Störzinger | Zendy; Stephan Borghorst | Zendy; Stefan Hofer | Zendy; Cornelius Busch | Zendy; Christoph Lichtenstern | Zendy; Georg Hempel | Zendy; Markus A. Weigand | Zendy; Torsten HoppeTichy | Zendy

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Plasma Concentrations of Posaconazole Administered via Nasogastric Tube in Patients in a Surgical Intensive Care Unit

Author(s) -

Dominic Störzinger,

Stephan Borghorst,

Stefan Hofer,

Cornelius Busch,

Christoph Lichtenstern,

Georg Hempel,

Markus A. Weigand,

Torsten HoppeTichy

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.06167-11

Subject(s) - posaconazole , pharmacokinetics , medicine , volume of distribution , intensive care unit , therapeutic drug monitoring , high performance liquid chromatography , population , anesthesia , chromatography , chemistry , voriconazole , antifungal , environmental health , dermatology

Abdominal surgery may affect intestinal absorption and the resulting levels of posaconazole in the blood. We measured plasma posaconazole levels in surgical intensive care unit (SICU) patients and tried to develop a predictive population pharmacokinetics model. A total of 270 samples from 15 patients receiving posaconazole via nasogastric tube were measured by high-performance liquid chromatography (HPLC). SICU patients showed lower plasma drug concentrations, a higher apparent clearance, and a higher volume of distribution than those in hematology patients, possibly due to poor absorption.

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