Acyclovir Achieves a Lower Concentration in African HIV-Seronegative, Herpes Simplex Virus 2-Seropositive Women than in Non-African Populations | Zendy

Yanhui Lu | Zendy; Connie Celum | Zendy; Anna Wald | Zendy; Jared M. Baeten | Zendy; Frances M. Cowan | Zendy; Sinéad DelanyMoretlwe | Zendy; Stewart E. Reid | Zendy; James P. Hughes | Zendy; Ellen Wilcox | Zendy; Lawrence Corey | Zendy; Craig W. Hendrix | Zendy

Open Access

Acyclovir Achieves a Lower Concentration in African HIV-Seronegative, Herpes Simplex Virus 2-Seropositive Women than in Non-African Populations

Author(s) -

Yanhui Lu,

Connie Celum,

Anna Wald,

Jared M. Baeten,

Frances M. Cowan,

Sinéad DelanyMoretlwe,

Stewart E. Reid,

James P. Hughes,

Ellen Wilcox,

Lawrence Corey,

Craig W. Hendrix

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.06160-11

Subject(s) - pharmacokinetics , herpes simplex virus , geometric mean , human immunodeficiency virus (hiv) , virus , virology , aciclovir , medicine , genital herpes , gastroenterology , viral disease , herpesviridae , mathematics , statistics

Acyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-time curve were 0.31 μg/ml and 1.59 h · μg/ml, respectively, 54% and 52% lower than values from non-Africans. Lower acyclovir concentrations may partly explain the reduced acyclovir suppression of HSV-2 genital ulcer recurrence in HPTN 039 African women participants.

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