Diverse Sequence Types of Klebsiella pneumoniae Contribute to the Dissemination of bla NDM-1 in India, Sweden, and the United Kingdom | Zendy

Christian G. Giske | Zendy; Inga Fröding | Zendy; Chowdhury M. Hasan | Zendy; Agata Turlej-Rogacka | Zendy; Mark A. Toleman | Zendy; David M. Livermore | Zendy; Neil Woodford | Zendy; Timothy R. Walsh | Zendy

Open Access

Diverse Sequence Types of Klebsiella pneumoniae Contribute to the Dissemination of bla _NDM-1 in India, Sweden, and the United Kingdom

Author(s) -

Christian G. Giske,

Inga Fröding,

Chowdhury M. Hasan,

Agata Turlej-Rogacka,

Mark A. Toleman,

David M. Livermore,

Neil Woodford,

Timothy R. Walsh

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.06142-11

Subject(s) - multilocus sequence typing , replicon , klebsiella pneumoniae , biology , plasmid , typing , serotype , microbiology and biotechnology , virulence , sequence (biology) , genetics , virology , gene , genotype , escherichia coli

Clinical isolates of Klebsiella pneumoniae producing NDM-1 carbapenemase from India (n = 22), the United Kingdom (n = 13), and Sweden (n = 4) were subjected to multilocus sequence typing (MLST), automated repetitive sequence-based PCR (rep-PCR), serotyping, virulence gene screening, and plasmid replicon typing. The most frequently detected MLST sequence types (STs) were ST14 (n = 13; all serotype K2), ST11, ST149, ST231, and ST147. The correlation between MLST and automated rep-PCR was excellent. IncA/C was the most frequently detected plasmid replicon type (n = 14). ST14, ST11, and other successful clones may be important for the dissemination of bla(NDM-1).

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