Recurrent Episodes of Candidemia Due to Candida glabrata with a Mutation in Hot Spot 1 of the FKS2 Gene Developed after Prolonged Therapy with Caspofungin | Zendy

María Teresa Durán-Valle | Zendy; Sara Gago | Zendy; Alicia GómezLópez | Zendy; Manuel CuencaEstrella | Zendy; Leticia Jiménez Díez-Canseco | Zendy; José Luís Gómez-Garcés | Zendy; Óscar Zaragoza | Zendy

Open Access

Recurrent Episodes of Candidemia Due to Candida glabrata with a Mutation in Hot Spot 1 of the FKS2 Gene Developed after Prolonged Therapy with Caspofungin

Author(s) -

María Teresa Durán-Valle,

Sara Gago,

Alicia GómezLópez,

Manuel CuencaEstrella,

Leticia Jiménez Díez-Canseco,

José Luís Gómez-Garcés,

Óscar Zaragoza

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.06100-11

Subject(s) - echinocandin , caspofungin , candida glabrata , echinocandins , biology , microbiology and biotechnology , micafungin , fungemia , medicine , voriconazole , antifungal , fluconazole

We report two episodes of recurrent candidemia caused by echinocandin-resistant Candida glabrata in a 69-year-old patient who underwent repeated abdominal surgery. In the first episode of candidemia, an echinocandin-susceptible Candida glabrata strain was isolated, and the patient was treated with caspofungin. The isolates from the later episodes showed resistance to echinocandins. Analysis of the HS1 region of the FKS2 gene showed the amino acid substitution S663P. Microsatellite analysis demonstrated a strong genetic relationship between the isolates.

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