“ tet (U)” Is Not a Tetracycline Resistance Determinant | Zendy

Jamie A. Caryl | Zendy; Georgina Cox | Zendy; Stefan Trimble | Zendy; Alex J. O’Neill | Zendy

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“ tet (U)” Is Not a Tetracycline Resistance Determinant

Author(s) -

Jamie A. Caryl,

Georgina Cox,

Stefan Trimble,

Alex J. O’Neill

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05957-11

Subject(s) - tetracycline , plasmid , rolling circle replication , genetics , gene , biology , antibiotics , dna replication

The enterococcal plasmid pKQ10 has been reported to carry a poorly characterized tetracycline resistance determinant designated tet(U). However, in a series of studies intended to further characterize this determinant, we have been unable to substantiate the claim that tet(U) confers resistance to tetracyclines. In line with these results, bioinformatic analysis provides compelling evidence that "tet(U)" is in fact the misannotated 3' end of a gene encoding a rolling-circle replication initiator (Rep) protein.

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