In Vitro Evaluation of Novel Compounds against Selected Resistant Pseudomonas aeruginosa Isolates | Zendy

Seth T. Housman | Zendy; Christina Sutherland | Zendy; David P. Nicolau | Zendy

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In Vitro Evaluation of Novel Compounds against Selected Resistant Pseudomonas aeruginosa Isolates

Author(s) -

Seth T. Housman,

Christina Sutherland,

David P. Nicolau

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05944-11

Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , in vitro , biology , multiple drug resistance , pseudomonadales , pseudomonadaceae , pseudomonas , minimum inhibitory concentration , chemistry , bacteria , antibiotics , genetics

We describe the activities of RX-P763, RX-P766, RX-P770, RX-P792, RX-P793, and RX-P808 against strains of resistant Pseudomonas aeruginosa. These compounds target the large subunit of the bacterial ribosome and have broad-spectrum activities against multidrug-resistant pathogens. All compounds demonstrated in vitro activity against P. aeruginosa, with MIC(90) values of 4 to 8 μg/ml (range, 0.5 to 64). These novel compounds had narrow MIC distributions and maintained activity despite resistance phenotypes to other commonly utilized agents.

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