Two Novel Class I Integron Arrays Containing IMP-18 Metallo-β-Lactamase Gene in Pseudomonas aeruginosa Clinical Isolates from Puerto Rico | Zendy

Teresa Martı́nez | Zendy; Guillermo J. Vázquez | Zendy; Edna E. Aquino | Zendy; Richard V. Goering | Zendy; Iraida E. Robledo | Zendy

Open Access

Two Novel Class I Integron Arrays Containing IMP-18 Metallo-β-Lactamase Gene in Pseudomonas aeruginosa Clinical Isolates from Puerto Rico

Author(s) -

Teresa Martı́nez,

Guillermo J. Vázquez,

Edna E. Aquino,

Richard V. Goering,

Iraida E. Robledo

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05758-11

Subject(s) - integron , pseudomonas aeruginosa , biology , microbiology and biotechnology , gene cassette , antibacterial agent , pseudomonadaceae , gene , bacteria , genetics , antibiotic resistance , antibiotics

During a β-lactam resistance surveillance study, 12 IMP-18-positive Pseudomonas aeruginosa isolates belonging to 9 different pulsed-field gel electrophoresis groups were identified. In nine isolates, a class I integron with a novel gene array was identified that contained bla(IMP-18) and bla(OXA-224), while in two isolates the class I integron contained bla(IMP-18) and bla(OXA-2) but in a new arrangement. Our findings show the dissemination of two novel class I integrons in P. aeruginosa from different regions of Puerto Rico.

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