Genetic and Biochemical Characterization of a Novel Metallo-β-Lactamase, TMB-1, from an Achromobacter xylosoxidans Strain Isolated in Tripoli, Libya | Zendy

Allaaeddin El Salabi | Zendy; P.S. Borra | Zendy; Mark A. Toleman | Zendy; Ørjan Samuelsen | Zendy; Timothy R. Walsh | Zendy

Open Access

Genetic and Biochemical Characterization of a Novel Metallo-β-Lactamase, TMB-1, from an Achromobacter xylosoxidans Strain Isolated in Tripoli, Libya

Author(s) -

Allaaeddin El Salabi,

P.S. Borra,

Mark A. Toleman,

Ørjan Samuelsen,

Timothy R. Walsh

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05640-11

Subject(s) - achromobacter xylosoxidans , integron , strain (injury) , microbiology and biotechnology , cephalosporin , biology , achromobacter , genetics , antibiotics , bacteria , pseudomonas , antibiotic resistance , anatomy

AnAchromobacter xylosoxidans strain from the Tripoli central hospital produced a unique metallo-β-lactamase, designated TMB-1, which is related to DIM-1 (62%) and GIM-1 (51%).bla TMB-1 was embedded in a class 1 integron and located on the chromosome. The TMB-1 β-lactamase has lowerk cat values than both DIM-1 and GIM-1 with cephalosporins and carbapenems. TheKm values were more similar to those of GIM-1 than those of DIM-1, with the overallk cat /Km values being lower than those for GIM-1 and DIM-1.

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