Open AccessTn 125 -Related Acquisition of bla NDM -Like Genes in Acinetobacter baumannii
Author(s) -
Laurent Poirel,
Rémy A. Bonnin,
Anne Boulanger,
Jacques Schrenzel,
Martin Kaase,
Patrice Nordmann
Publication year - 2012
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.05620-11
Subject(s) - acinetobacter baumannii , transposable element , gene , biology , insertion sequence , plasmid , dna transposable elements , microbiology and biotechnology , genetics , multiple drug resistance , acinetobacter , drug resistance , genome , antibiotics , bacteria , pseudomonas aeruginosa
A multidrug-resistantAcinetobacter baumannii isolate recovered from a patient hospitalized in Switzerland after a transfer from Serbia produced the NDM-1 carbapenemase. Thebla NDM-1 gene was part of a chromosomally located Tn125 composite transposon bracketed by two copies of the same insertion sequence, ISAba125 . This transposon was also associated with the acquisition and expression of thebla NDM-2 gene in anA. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissemination ofbla NDM genes in that species.