Open AccessSurvey of Antimicrobial Resistance in Clinical Burkholderia pseudomallei Isolates over Two Decades in Northeast Thailand
Author(s) -
Vanaporn Wuthiekanun,
Premjit Amornchai,
Natnaree Saiprom,
Narisara Chantratita,
Wirongrong Chierakul,
Gavin Koh,
Wipada Chaowagul,
Nicholas Day,
Direk Limmathurotsakul,
Sharon J. Peacock
Publication year - 2011
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.05517-11
Subject(s) - burkholderia pseudomallei , melioidosis , microbiology and biotechnology , antimicrobial , burkholderia , biology , antibiotic resistance , antibiotics , bacteria , genetics
A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0.6%) patients with one or more isolates resistant to ceftazidime (n = 8), amoxicillin-clavulanic acid (n = 4), or both drugs (n = 12). Two cases were identified at admission, and the remainder were detected a median of 15 days after starting antimicrobial therapy. Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis.