Phenotypic Changes in Artemisinin-Resistant Plasmodium falciparum Lines In Vitro : Evidence for Decreased Sensitivity to Dormancy and Growth Inhibition | Zendy

Franka Teuscher | Zendy; Nanhua Chen | Zendy; Dennis E. Kyle | Zendy; Michelle L. Gatton | Zendy; Qin Cheng | Zendy

Open Access

Phenotypic Changes in Artemisinin-Resistant Plasmodium falciparum Lines In Vitro : Evidence for Decreased Sensitivity to Dormancy and Growth Inhibition

Author(s) -

Franka Teuscher,

Nanhua Chen,

Dennis E. Kyle,

Michelle L. Gatton,

Qin Cheng

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05456-11

Subject(s) - dormancy , artemisinin , plasmodium falciparum , biology , phenotype , in vivo , in vitro , malaria , botany , genetics , immunology , gene , germination

The appearance of Plasmodium falciparum parasites with decreased in vivo sensitivity but no measurable in vitro resistance to artemisinin has raised the urgent need to characterize the artemisinin resistance phenotype. Changes in the temporary growth arrest (dormancy) profile of parasites may be one aspect of this phenotype. In this study, we investigated the link between dormancy and resistance, using artelinic acid (AL)-resistant parasites. Our results demonstrate that the AL resistance phenotype has (i) decreased sensitivity of mature-stage parasites, (ii) decreased sensitivity of the ring stage to the induction of dormancy, and (iii) a faster recovery from dormancy.

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