Open AccessIn Vivo Activity of Aryl Ozonides against Schistosoma Species
Author(s) -
Jennifer Keiser,
Katrin Ingram,
Mireille Vargas,
Jacques Chollet,
Xiaofang Wang,
Yuxiang Dong,
Jonathan L. Vennerstrom
Publication year - 2011
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.05371-11
Subject(s) - schistosoma mansoni , in vivo , schistosoma , biology , pharmacology , schistosomiasis , chemistry , microbiology and biotechnology , toxicology , helminths , immunology
We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P < 0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.
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