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In ICESp2905 , a widespreaderm (TR)- andtet (O)-carrying genetic element ofStreptococcus pyogenes , the two resistance determinants are contained in separate fragments inserted into a scaffold of clostridial origin. ICESp2905 (∼65.6 kb) was transferable not only in its regular form but also in a defective form lacking theerm (TR) fragment (ICESp2906 , ∼53.0 kb). Theerm (TR) fragment was also an independent integrative and conjugative element (ICE) (ICESp2907 , ∼12.6 kb). ICESp2905 thus results from one ICE (ICESp2907 ) being integrated into another (ICESp2906 ).

antimicrobial agents and chemotherapy

ICE Sp2905 , the erm (TR)- tet (O) Element of Streptococcus pyogenes, Is Formed by Two Independent Integrative and Conjugative Elements