Genetic Features of the Widespread Plasmid Coding for the Carbapenemase OXA-48 | Zendy

Laurent Poirel | Zendy; Rémy A. Bonnin | Zendy; Patrice Nordmann | Zendy

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Genetic Features of the Widespread Plasmid Coding for the Carbapenemase OXA-48

Author(s) -

Laurent Poirel,

Rémy A. Bonnin,

Patrice Nordmann

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05289-11

Subject(s) - plasmid , klebsiella pneumoniae , transposable element , biology , genetics , gene , coding region , microbiology and biotechnology , escherichia coli , genome

Complete sequencing of plasmid pOXA-48a carrying thebla OXA-48 gene from aKlebsiella pneumoniae isolate was performed. Its backbone corresponded to that of an IncL/M-type plasmid, in which thebla OXA-48 gene had been integrated through the acquisition of the Tn1999 composite transposon without any other antibiotic resistance gene. Molecular epidemiology using a collection of international OXA-48 producers revealed the wide diffusion of pOXA-48a or closely related plasmids.

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