Occidiofungin's Chemical Stability and In Vitro Potency against Candida Species | Zendy

Dayna Ellis | Zendy; Jiten Gosai | Zendy; Charles Emrick | Zendy; Rachel Heintz | Zendy; Lanette Romans | Zendy; Donna M. Gordon | Zendy; ShiEn Lu | Zendy; Frank W. Austin | Zendy; Leif Smith | Zendy

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Occidiofungin's Chemical Stability and In Vitro Potency against Candida Species

Author(s) -

Dayna Ellis,

Jiten Gosai,

Charles Emrick,

Rachel Heintz,

Lanette Romans,

Donna M. Gordon,

ShiEn Lu,

Frank W. Austin,

Leif Smith

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05231-11

Subject(s) - potency , candida albicans , in vitro , lipopeptide , microbiology and biotechnology , proteases , biology , chemistry , biochemistry , bacteria , enzyme , genetics

Occidiofungin is a cyclic glyco-lipopeptide produced byBurkholderia contaminans . MICs againstCandida species were between 0.5 and 2.0 μg/ml. Occidiofungin retains itsin vitro potency in the presence of 5% and 50% human serum with a minimal lethal concentration (MLC) of 2 and 4 μg/ml, respectively. Time-kill and postantifungal effect (PAFE) experiments of occidiofungin againstCandida albicans were performed. The results demonstrate that occidiofungin is fungicidal. Occidiofungin was also found to be a very stable molecule. It is resistant to extreme temperatures and pH and maintains its activity following exposure to gastric proteases.

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