Open AccessInfrequent Finding of Metallo-β-Lactamase VIM-2 in Carbapenem-Resistant Pseudomonas aeruginosa Strains from Croatia
Author(s) -
Sanda Sardelić,
Branka Bedenić,
Céline Coli-Dupuich,
Stjepan Orhanović,
Zrinka Bošnjak,
Vanda Plečko,
Benoît Cournoyer,
Gian María Rossolini
Publication year - 2012
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.05212-11
Subject(s) - integron , colistin , amikacin , imipenem , microbiology and biotechnology , pseudomonas aeruginosa , carbapenem , biology , serotype , antibiotics , bacteria , antibiotic resistance , genetics
One hundred sixty-nine nonreplicate imipenem-resistantPseudomonas aeruginosa strains isolated in a large hospital on the coastal region of Croatia were studied. The most active antibiotics were colistin and amikacin. Most of the isolates were multiresistant. The most prevalent serotype was O12, followed by O11. Six strains carried thebla VIM-2 gene located in a novel class 1 integron composed in its variable part of thebla VIM-2 -bla oxa-10 -ΔqacF-aacA4 genes. Metallo-β-lactamase-producing strains belonged to sequence types ST235 and ST111.