Open AccessA Novel New Delhi Metallo-β-Lactamase Variant, NDM-14, Isolated in a Chinese Hospital Possesses Increased Enzymatic Activity against Carbapenems
Author(s) -
Dayang Zou,
Yong Huang,
Xiangna Zhao,
Wei Liu,
Derong Dong,
Huan Li,
Xuesong Wang,
Simo Huang,
Xiao Wei,
Xiabei Yan,
Zhan Yang,
Yigang Tong,
Liuyu Huang,
Jing Yuan
Publication year - 2015
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.05168-14
Subject(s) - meropenem , imipenem , acinetobacter , new delhi , enzyme , microbiology and biotechnology , carbapenem , intensive care unit , chemistry , biology , medicine , antibiotics , biochemistry , antibiotic resistance , intensive care medicine , metropolitan area , pathology
A novel New Delhi metallo-β-lactamase (NDM) variant, NDM-14, was identified in clinical isolateAcinetobacter lwoffii JN49-1, which was recovered from an intensive care unit patient at a local hospital in China. NDM-14, which differs from other existing enzymes by an amino acid substitution at position 130 (Asp130Gly), possesses enzymatic activity toward carbapenems that is greater than that of NDM-1. Kinetic data indicate that NDM-14 has a higher affinity for imipenem and meropenem.
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