Dissemination of the Fosfomycin Resistance Gene fosA3 with CTX-M β-Lactamase Genes and rmtB Carried on IncFII Plasmids among Escherichia coli Isolates from Pets in China | Zendy

Jianxia Hou | Zendy; Xi Huang | Zendy; Yuting Deng | Zendy; Liang-Ying He | Zendy; Tong Yang | Zendy; Zhenling Zeng | Zendy; Chen Zhang-liu | Zendy; Jian–Hua Liu | Zendy

Open Access

Dissemination of the Fosfomycin Resistance Gene fosA3 with CTX-M β-Lactamase Genes and rmtB Carried on IncFII Plasmids among Escherichia coli Isolates from Pets in China

Author(s) -

Jianxia Hou,

Xi Huang,

Yuting Deng,

Liang-Ying He,

Tong Yang,

Zhenling Zeng,

Chen Zhang-liu,

Jian–Hua Liu

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05104-11

Subject(s) - fosfomycin , plasmid , escherichia coli , biology , gene , microbiology and biotechnology , beta lactamase , genetics , enterobacteriaceae , antibiotics

The presence and characterization of plasmid-mediated fosfomycin resistance determinants among Escherichia coli isolates collected from pets in China between 2006 and 2010 were investigated. Twenty-nine isolates (9.0%) were positive for fosA3, and all of them were CTX-M producers. The fosA3 genes were flanked by IS26 and were localized on F2:A-:B- plasmids or on very similar F33:A-:B- plasmids carrying both bla(CTX-M-65) and rmtB. These findings indicate that the fosA3 gene may be coselected by antimicrobials other than fosfomycin.

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