Impact of β-Lactamase Inhibition on the Activity of Ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus | Zendy

Vincent Dubée | Zendy; Daria Soroka | Zendy; Mélanie Cortès | Zendy; Anne-Laure Lefebvre | Zendy; Laurent Gutmann | Zendy; JeanEmmanuel Hugonnet | Zendy; Michel Arthur | Zendy; JeanLuc Mainardi | Zendy

Open Access

Impact of β-Lactamase Inhibition on the Activity of Ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus

Author(s) -

Vincent Dubée,

Daria Soroka,

Mélanie Cortès,

Anne-Laure Lefebvre,

Laurent Gutmann,

JeanEmmanuel Hugonnet,

Michel Arthur,

JeanLuc Mainardi

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05080-14

Subject(s) - mycobacterium abscessus , mycobacterium tuberculosis , microbiology and biotechnology , mycobacterium , tuberculosis , cephalosporin , drug resistance , medicine , antibiotics , biology , pathology

The production of β-lactamases Bla(Mab) and BlaC contributes to β-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis, respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from ≥ 256 to 16 to 64 μg/ml, but these values are clinically irrelevant. In contrast, the ceftaroline-avibactam combination should be evaluated against M. abscessus since it inhibited growth at lower and potentially achievable drug concentrations.

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