Predominance of KPC-3 in a Survey for Carbapenemase-Producing Enterobacteriaceae in Portugal | Zendy

Vera Manageiro | Zendy; Eugénia Ferreira | Zendy; Joana Almeida | Zendy; Stephanie Barbosa | Zendy; Constança Simões | Zendy; Robert A. Bonomo | Zendy; Manuela Caniça | Zendy

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Predominance of KPC-3 in a Survey for Carbapenemase-Producing Enterobacteriaceae in Portugal

Author(s) -

Vera Manageiro,

Eugénia Ferreira,

Joana Almeida,

Stephanie Barbosa,

Constança Simões,

Robert A. Bonomo,

Manuela Caniça

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05065-14

Subject(s) - enterobacter cloacae , enterobacter aerogenes , klebsiella oxytoca , klebsiella pneumoniae , enterobacteriaceae , microbiology and biotechnology , biology , plasmid , enterobacter , escherichia coli , gene , genetics

Among the 2,105Enterobacteriaceae tested in a survey done in Portugal, 165 were nonsusceptible to carbapenems, from which 35 (26Klebsiella pneumoniae , 3Escherichia coli , 2Enterobacter aerogenes , and 3Enterobacter cloacae isolates and 1Klebsiella oxytoca isolate) were confirmed to be carbapenemase producers by the presence of 30Tn 4401d-bla KPC-3 , 4intI 3-bla GES-5 , and oneintI 1-bla VIM-2 gene, alone or in combination with otherbla genes. The dissemination ofbla KPC-3 gene carried by an IncF plasmid suggests lateral gene transfer as a major mechanism of dissemination.

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