Ibuprofen Potentiates the In Vivo Antifungal Activity of Fluconazole against Candida albicans Murine Infection | Zendy

Sofia CostadeOliveira | Zendy; Isabel M. Miranda | Zendy; Ana Silva-Dias | Zendy; Ana P. Silva | Zendy; Acácio G. Rodrigues | Zendy; Cidália PinaVaz | Zendy

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Ibuprofen Potentiates the In Vivo Antifungal Activity of Fluconazole against Candida albicans Murine Infection

Author(s) -

Sofia CostadeOliveira,

Isabel M. Miranda,

Ana Silva-Dias,

Ana P. Silva,

Acácio G. Rodrigues,

Cidália PinaVaz

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05056-14

Subject(s) - fluconazole , candida albicans , fungemia , microbiology and biotechnology , azole , efflux , in vivo , pharmacology , ibuprofen , mycosis , antifungal , medicine , drug resistance , corpus albicans , biology , immunology , genetics

Candida albicans is the most prevalent cause of fungemia worldwide. Its ability to develop resistance in patients receiving azole antifungal therapy is well documented. In a murine model of systemic infection, we show that ibuprofen potentiates fluconazole antifungal activity against a fluconazole-resistant strain, drastically reducing the fungal burden and morbidity. The therapeutic combination of fluconazole with ibuprofen may constitute a new approach for the management of antifungal therapeutics to reverse the resistance conferred by efflux pump overexpression.

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