Kidney Injury Associated with Telavancin Dosing Regimen in an Animal Model | Zendy

Vincent H. Tam | Zendy; Kimberly R. Ledesma | Zendy; Dana R. Bowers | Zendy; Jian Zhou | Zendy; Luan D. Truong | Zendy

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Kidney Injury Associated with Telavancin Dosing Regimen in an Animal Model

Author(s) -

Vincent H. Tam,

Kimberly R. Ledesma,

Dana R. Bowers,

Jian Zhou,

Luan D. Truong

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.05002-14

Subject(s) - dosing , regimen , medicine , pharmacology , animal model , acute kidney injury

The elevation of serum creatinine levels is a concern with telavancin therapy. We examined the onset of kidney injury associated with telavancin in an animal model. Urine samples were collected at baseline and daily to determine the concentrations of kidney injury molecule 1 (KIM-1), a marker for early kidney injury. When a clinically relevant exposure of telavancin was given daily to rats, some differences in kidney injury were attributed to the dosing regimen. Further investigations of alternative telavancin dosing regimens are warranted.

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