Open AccessThe Brain, Amphotericin B, and P-Glycoprotein
Author(s) -
David A. Stevens,
Karl V. Clemons,
Marife Martinez,
Vicky Chen
Publication year - 2015
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.04768-14
Subject(s) - amphotericin b , pharmacology , medicine , p glycoprotein , microbiology and biotechnology , antibiotics , biology , antifungal , multiple drug resistance
We read with interest the paper by Wu et al. ([1][1]) purporting to show that blockade of P-glycoprotein with verapamil or itraconazole increased brain concentrations of amphotericin B (AMB). Because virtually all P-glycoprotein blockers also block other transporters, we chose to compare P-
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