Colistin Resistance Mechanisms in Klebsiella pneumoniae Strains from Taiwan | Zendy

Yi-Hsiang Cheng | Zendy; Tzu-Lung Lin | Zendy; YiJiun Pan | Zendy; YuPing Wang | Zendy; Yi-Tsung Lin | Zendy; Jin-Town Wang | Zendy

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Colistin Resistance Mechanisms in Klebsiella pneumoniae Strains from Taiwan

Author(s) -

Yi-Hsiang Cheng,

Tzu-Lung Lin,

YiJiun Pan,

YuPing Wang,

Yi-Tsung Lin,

Jin-Town Wang

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.04763-14

Subject(s) - colistin , klebsiella pneumoniae , microbiology and biotechnology , antibiotics , biology , enterobacteriaceae , escherichia coli , gene , genetics

Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance.

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