In Vivo Effect of Flucloxacillin in Experimental Endocarditis Caused by mecC -positive Staphylococcus aureus Showing Temperature-Dependent Susceptibility In Vitro | Zendy

Stefano Mancini | Zendy; Frédéric Laurent | Zendy; Tiago Rafael Veloso | Zendy; Marlyse Giddey | Zendy; Jacques Vouillamoz | Zendy; François Vandenesch | Zendy; Philippe Moreillon | Zendy; José M. Entenza | Zendy

Open Access

In Vivo Effect of Flucloxacillin in Experimental Endocarditis Caused by mecC -positive Staphylococcus aureus Showing Temperature-Dependent Susceptibility In Vitro

Author(s) -

Stefano Mancini,

Frédéric Laurent,

Tiago Rafael Veloso,

Marlyse Giddey,

Jacques Vouillamoz,

François Vandenesch,

Philippe Moreillon,

José M. Entenza

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.04733-14

Subject(s) - flucloxacillin , staphylococcus aureus , microbiology and biotechnology , in vivo , endocarditis , staphylococcal infections , in vitro , antibiotics , methicillin resistant staphylococcus aureus , biology , medicine , chemistry , bacteria , surgery , biochemistry , genetics

Methicillin-resistantStaphylococcus aureus (MRSA) carrying themecC gene (mecC -MRSA) exhibited at 37°C MICs of oxacillin close to those of methicillin-susceptibleS. aureus (MSSA). We investigated whether at this temperature,mecC -MRSA strains respond to flucloxacillin treatment like MSSA strains, using a rat model of endocarditis. Flucloxacillin (human-like kinetics of 2 g intravenously every 6 h) cured 80 to 100% of aortic vegetations infected with five differentmecC -MRSA strains. These results suggest thatmecC -MRSA infections may successfully respond to treatment with β-lactams.

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