Caprylic Acid and Glyceryl Trinitrate Combination for Eradication of Biofilm | Zendy

Joel Rosenblatt | Zendy; Ruth Reitzel | Zendy; Issam Raad | Zendy

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Caprylic Acid and Glyceryl Trinitrate Combination for Eradication of Biofilm

Author(s) -

Joel Rosenblatt,

Ruth Reitzel,

Issam Raad

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.04561-14

Subject(s) - caprylic acid , biofilm , antibiotics , microbiology and biotechnology , antimicrobial , antibiotic resistance , chemistry , bacteria , biology , biochemistry , fatty acid , genetics

There is a growing need for biocompatible, broad-spectrum, nonantibiotic, antimicrobial treatments because of the frequent ineffectiveness of antibiotics against biofilms and the increasing incidence of antibiotic resistance. In this study, we demonstrate rapid and complete biofilm eradication in anin vitro model with synergistic combinations of glyceryl trinitrate and caprylic acid against resistant Gram-positive, Gram-negative, and fungal biofilms.

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