Fluoroquinolone Resistance Does Not Impose a Cost on the Fitness of Clostridium difficile In Vitro | Zendy

François Wasels | Zendy; Sarah A. Kuehne | Zendy; Stephen T. Cartman | Zendy; Patrizia Spigaglia | Zendy; Fabrizio Barbanti | Zendy; Nigel P. Minton | Zendy; Paola Mastrantonio | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Fluoroquinolone Resistance Does Not Impose a Cost on the Fitness of Clostridium difficile In Vitro

Author(s) -

François Wasels,

Sarah A. Kuehne,

Stephen T. Cartman,

Patrizia Spigaglia,

Fabrizio Barbanti,

Nigel P. Minton,

Paola Mastrantonio

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.04503-14

Subject(s) - clostridium difficile , microbiology and biotechnology , clone (java method) , biology , strain (injury) , point mutation , antibiotics , in vitro , clostridium , drug resistance , gene , mutant , mutation , clostridiaceae , bacteria , genetics , anatomy

Point mutations conferring resistance to fluoroquinolones were introduced in the gyr genes of the reference strain Clostridium difficile 630. Only mutants with the substitution Thr-82→Ile in GyrA, which characterizes the hypervirulent epidemic clone III/027/NAP1, were resistant to all fluoroquinolones tested. The absence of a fitness cost in vitro for the most frequent mutations detected in resistant clinical isolates suggests that resistance will be maintained even in the absence of antibiotic pressure.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research