In Vitro Fungicidal Activities of Anidulafungin, Caspofungin, and Micafungin against Candida glabrata, Candida bracarensis, and Candida nivariensis Evaluated by Time-Kill Studies | Zendy

Sandra Gil-Alonso | Zendy; Nerea Jauregizar | Zendy; Emilia Cantón | Zendy; Elena Eraso | Zendy; Guillermo Quindós | Zendy

Open Access

In Vitro Fungicidal Activities of Anidulafungin, Caspofungin, and Micafungin against Candida glabrata, Candida bracarensis, and Candida nivariensis Evaluated by Time-Kill Studies

Author(s) -

Sandra Gil-Alonso,

Nerea Jauregizar,

Emilia Cantón,

Elena Eraso,

Guillermo Quindós

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.04474-14

Subject(s) - anidulafungin , micafungin , caspofungin , candida glabrata , echinocandins , microbiology and biotechnology , echinocandin , fungicide , in vitro , candida albicans , fluconazole , candida dubliniensis , fungi imperfecti , biology , chemistry , antifungal , biochemistry , botany , corpus albicans

Anidulafungin, caspofungin, and micafungin killing activities against Candida glabrata, Candida bracarensis, and Candida nivariensis were evaluated by the time-kill methodology. The concentrations assayed were 0.06, 0.125, and 0.5 μg/ml, which are achieved in serum. Anidulafungin and micafungin required between 13 and 26 h to reach the fungicidal endpoint (99.9% killing) against C. glabrata and C. bracarensis. All echinocandins were less active against C. nivariensis.

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