Susceptibility Profiles of Amphotericin B and Posaconazole against Clinically Relevant Mucorales Species under Hypoxic Conditions | Zendy

Elisabeth Maurer | Zendy; Ulrike Binder | Zendy; Manuela Sparber | Zendy; Michaela Lackner | Zendy; Rita Caramalho | Zendy; Cornelia LassFlörl | Zendy

Open Access

Susceptibility Profiles of Amphotericin B and Posaconazole against Clinically Relevant Mucorales Species under Hypoxic Conditions

Author(s) -

Elisabeth Maurer,

Ulrike Binder,

Manuela Sparber,

Michaela Lackner,

Rita Caramalho,

Cornelia LassFlörl

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.04424-14

Subject(s) - mucorales , posaconazole , amphotericin b , biology , microbiology and biotechnology , mucormycosis , antifungal , medicine , pathology

The effect of hypoxic conditions on the in vitro efficacy of amphotericin B and posaconazole against Mucorales was evaluated by defining MICs with Etest and broth microdilution and identifying minimal fungicidal concentrations (MFCs). With Etest, oxygen-dependent changes were detected, while the MIC and the MFC determined with broth microdilution remained unaltered with reduced oxygen levels. The observed differences depended on the method used.

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