High Prevalence of bla NDM-1 Carbapenemase-Encoding Gene and 16S rRNA armA Methyltransferase Gene among Acinetobacter baumannii Clinical Isolates in Egypt | Zendy

Mohamed Abd El-Gawad El-Sayed Ahmed | Zendy; Magdy Ali Amin | Zendy; Wael M. Tawakol | Zendy; Lotfi Loucif | Zendy; Sofiane Bakour | Zendy; JeanMarc Rolain | Zendy

Open Access

High Prevalence of bla _NDM-1 Carbapenemase-Encoding Gene and 16S rRNA armA Methyltransferase Gene among Acinetobacter baumannii Clinical Isolates in Egypt

Author(s) -

Mohamed Abd El-Gawad El-Sayed Ahmed,

Magdy Ali Amin,

Wael M. Tawakol,

Lotfi Loucif,

Sofiane Bakour,

JeanMarc Rolain

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.04412-14

Subject(s) - multilocus sequence typing , acinetobacter baumannii , biology , 16s ribosomal rna , gene , acinetobacter , typing , genetics , microbiology and biotechnology , ribosomal rna , genotype , bacteria , pseudomonas aeruginosa

The main objective of this study was to decipher the molecular mechanism of resistance to carbapenems and aminoglycosides in a large series of 150 Acinetobacter baumannii clinical isolates collected from July 2012 to September 2013 in Egypt. We report for the first time the emergence of bla(NDM-1) and the cooccurrence of 16S rRNA methylase armA with bla(NDM-1) and bla(OXA-23) in Egyptian hospitals. Multilocus sequence typing identified 27 distinct sequence types, 11 of which were novel.

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