ClpP-Independent Function of ClpX Interferes with Telithromycin Resistance Conferred by Msr(A) in Staphylococcus aureus | Zendy

Vladimir Vimberg | Zendy; Jakub Lenart | Zendy; Jiřı́ Janata | Zendy; Gabriela Balíková Novotná | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

ClpP-Independent Function of ClpX Interferes with Telithromycin Resistance Conferred by Msr(A) in Staphylococcus aureus

Author(s) -

Vladimir Vimberg,

Jakub Lenart,

Jiřı́ Janata,

Gabriela Balíková Novotná

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.04367-14

Subject(s) - staphylococcus aureus , telithromycin , microbiology and biotechnology , function (biology) , biology , staphylococcus , bacteria , chemistry , antibiotics , antibacterial agent , genetics

The ABCF family protein Msr(A) confers high resistance to macrolides but only low resistance to ketolides in staphylococci. Mutations in conserved functional regions of ClpX as well as deletion ofclpX significantly increased Msr(A)-mediated resistance to the ketolide antibiotic telithromycin. ClpX is the chaperone component of the ClpXP two-component proteolytic system. Nevertheless, no changes in resistance were observed in aclpP knockout strain expressingmsr (A), demonstrating that ClpX affects Msr(A) independently of ClpP.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research