Open Accessbla NDM-5 Carried by an IncX3 Plasmid in Escherichia coli Sequence Type 167
Author(s) -
Ping Yang,
Yi Xie,
Ping Feng,
Zhiyong Zong
Publication year - 2014
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.03911-14
Subject(s) - plasmid , escherichia coli , context (archaeology) , enterobacteriaceae , sequence (biology) , biology , strain (injury) , microbiology and biotechnology , gene , genetics , anatomy , paleontology
bla NDM-5 was found inEscherichia coli strain 0215 from a Chinese patient without travel history. Genomic sequencing and conjugation experiments were performed. Strain 0215 belonged to sequence type 167 (ST167) and had other resistance determinants, includingbla TEM-135 ,bla CTX-M-14 , andaac (6 ′)-Ib. bla NDM-5 was carried by a 47-kb self-transmissible IncX3 plasmid and was in a complex genetic context similar to that ofbla NDM-1 on IncX3 plasmids. IncX3 plasmids might have emerged as a common vehicle mediating the spread ofbla NDM .
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom