Metallo-β-Lactamase-Producing Bacteroides Species Can Shield Other Members of the Gut Microbiota from Antibiotics | Zendy

Usha Stiefel | Zendy; Mary Ann Tima | Zendy; Michelle M. Nerandzic | Zendy

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Metallo-β-Lactamase-Producing Bacteroides Species Can Shield Other Members of the Gut Microbiota from Antibiotics

Author(s) -

Usha Stiefel,

Mary Ann Tima,

Michelle M. Nerandzic

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03719-14

Subject(s) - bacteroides , microbiology and biotechnology , antibiotics , ceftriaxone , bacteroides fragilis , biology , gut flora , incubation , escherichia coli , bacteria , immunology , genetics , biochemistry , gene

Antibiotics disrupt the intestinal microbiota, rendering patients vulnerable to colonization by exogenous pathogens. Intermicrobial interactions may attenuate this effect. Incubation with ceftriaxone-resistant,ccrA -positive, β-lactamase-producingBacteroides strains raised the minimum bactericidal concentration of ceftriaxone required to kill a susceptibleEscherichia coli strain (mean change, <0.25 to 29 mg/liter;P = 0.009); incubation with ceftriaxone-resistant but non-β-lactamase-producingBacteroides strains had no effect. The production of β-lactamase by common members of the intestinal microbiota (Bacteroides ) can protect susceptible fellow commensals from β-lactams.

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