Open AccessComplete Sequence of a Conjugative IncN Plasmid Harboring bla KPC-2 , bla SHV-12 , and qnrS1 from an Escherichia coli Sequence Type 648 Strain
Author(s) -
Junjie Li,
ChangSeop Lee,
Jifang Sheng,
Yohei Doi
Publication year - 2014
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.03632-14
Subject(s) - plasmid , escherichia coli , biology , klebsiella pneumoniae , enterobacteriaceae , microbiology and biotechnology , genetics , insertion sequence , gene , transposable element , genome
We sequenced a novel conjugative blaKPC-2-harboring IncN plasmid, pYD626E, from an Escherichia coli sequence type 648 strain previously identified in Pittsburgh, Pennsylvania. pYD626E was 72,800 bp long and carried four β-lactamase genes, blaKPC-2, blaSHV-12, blaLAP-1, and blaTEM-1. In addition, it harbored qnrS1 (fluoroquinolone resistance) and dfrA14 (trimethoprim resistance). The plasmid profile and clinical history supported the in vivo transfer of this plasmid between Klebsiella pneumoniae and Escherichia coli.
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