Population Pharmacokinetics of Abacavir in Pregnant Women | Zendy

Floris Fauchet | Zendy; JeanMarc Tréluyer | Zendy; LaureHélène Préta | Zendy; Elodie Valade | Zendy; E. Pannier | Zendy; Saı̈k Urien | Zendy; Déborah Hirt | Zendy

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Population Pharmacokinetics of Abacavir in Pregnant Women

Author(s) -

Floris Fauchet,

JeanMarc Tréluyer,

LaureHélène Préta,

Elodie Valade,

E. Pannier,

Saı̈k Urien,

Déborah Hirt

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03469-14

Subject(s) - abacavir , pharmacokinetics , medicine , regimen , pregnancy , population pharmacokinetics , population , dosing , obstetrics , gestational age , human immunodeficiency virus (hiv) , pharmacology , antiretroviral therapy , biology , viral load , environmental health , genetics , family medicine

For the first time, a population approach was used to describe abacavir (ABC) pharmacokinetics in HIV-infected pregnant and nonpregnant women. A total of 266 samples from 150 women were obtained. No covariate effect (from age, body weight, pregnancy, or gestational age) on ABC pharmacokinetics was found. Thus, it seems unnecessary to adapt the ABC dosing regimen during pregnancy.

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