Beneficial Effect of Oral Tigecycline Treatment on Clostridium difficile Infection in Gnotobiotic Piglets | Zendy

Hyeun Bum Kim | Zendy; Quanshun Zhang | Zendy; Xingmin Sun | Zendy; Gillian Beamer | Zendy; Yuankai Wang | Zendy; Saul Tzipori | Zendy

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Beneficial Effect of Oral Tigecycline Treatment on Clostridium difficile Infection in Gnotobiotic Piglets

Author(s) -

Hyeun Bum Kim,

Quanshun Zhang,

Xingmin Sun,

Gillian Beamer,

Yuankai Wang,

Saul Tzipori

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03447-14

Subject(s) - tigecycline , clostridium difficile , microbiology and biotechnology , antibiotics , medicine , biology

The efficacy of oral tigecycline treatment (2 mg/kg of body weight for 7 days) ofClostridium difficile infection (CDI) was evaluated in the gnotobiotic pig model, and its effect on human gut microflora transplanted into the gnotobiotic pig was determined. Tigecycline oral treatment improved survival, clinical signs, and lesion severity and markedly decreased concentrations ofFirmicutes but did not promote CDI. Our data showed that oral tigecycline treatment has a potential beneficial effect on the treatment of CDI.

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