Agmatine-Containing Poly(amidoamine)s as a Novel Class of Antiviral Macromolecules: Structural Properties and In Vitro Evaluation of Infectivity Inhibition | Zendy

Manuela Donalisio | Zendy; Elisabetta Ranucci | Zendy; Valeria Cagno | Zendy; Andrea Civra | Zendy; Amedea Manfredi | Zendy; Roberta Cavalli | Zendy; Paolo Ferruti | Zendy; David Lembo | Zendy

Open Access

Agmatine-Containing Poly(amidoamine)s as a Novel Class of Antiviral Macromolecules: Structural Properties and In Vitro Evaluation of Infectivity Inhibition

Author(s) -

Manuela Donalisio,

Elisabetta Ranucci,

Valeria Cagno,

Andrea Civra,

Amedea Manfredi,

Roberta Cavalli,

Paolo Ferruti,

David Lembo

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03420-14

Subject(s) - vesicular stomatitis virus , infectivity , in vitro , poly(amidoamine) , virology , herpes simplex virus , chemistry , rhinovirus , virus , agmatine , amidoamine , biology , biochemistry , dendrimer , putrescine , enzyme

Poly(amidoamine)s (PAAs) are multifunctional tert-amine polymers endowed with high structural versatility. Here we report on the screening of a minilibrary of PAAs against a panel of viruses. The PAA AGMA1 showed antiviral activity against herpes simplex virus, human cytomegalovirus, human papillomavirus 16, and respiratory syncytial virus but not against human rotavirus and vesicular stomatitis virus. The results suggest the contribution of both a polycationic nature and side guanidine groups in imparting antiviral activity.

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