NDM-12, a Novel New Delhi Metallo-β-Lactamase Variant from a Carbapenem-Resistant Escherichia coli Clinical Isolate in Nepal | Zendy

Tatsuya Tada | Zendy; Basudha Shrestha | Zendy; Tohru MiyoshiAkiyama | Zendy; Kayo Shimada | Zendy; Hiroshi Ohara | Zendy; Teruo Kirikae | Zendy; Bharat Mani Pokhrel | Zendy

Open Access

NDM-12, a Novel New Delhi Metallo-β-Lactamase Variant from a Carbapenem-Resistant Escherichia coli Clinical Isolate in Nepal

Author(s) -

Tatsuya Tada,

Basudha Shrestha,

Tohru MiyoshiAkiyama,

Kayo Shimada,

Hiroshi Ohara,

Teruo Kirikae,

Bharat Mani Pokhrel

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03355-14

Subject(s) - doripenem , escherichia coli , carbapenem , microbiology and biotechnology , new delhi , plasmid , enterobacteriaceae , ertapenem , biology , meropenem , gene , antibiotics , medicine , antibiotic resistance , genetics , metropolitan area , pathology

A novel New Delhi metallo-β-lactamase variant, NDM-12, was identified in a carbapenem-resistantEscherichia coli clinical isolate obtained from a urine sample from a patient in Nepal. NDM-12 differed from NDM-1 by two amino acid substitutions (M154L and G222D). The enzymatic activities of NDM-12 against β-lactams were similar to those of NDM-1, although NDM-12 showed lowerk cat /Km ratios for all β-lactams tested except doripenem. Thebla NDM-12 gene was located in a plasmid of 160 kb.

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