Characterization of Tn 6238 with a New Allele of aac(6′)-Ib-cr | Zendy

María Paula Quiroga | Zendy; Betina Orman | Zendy; Laura Errecalde | Zendy; Sara Kaufman | Zendy; Daniela Centrón | Zendy

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Characterization of Tn 6238 with a New Allele of aac(6′)-Ib-cr

Author(s) -

María Paula Quiroga,

Betina Orman,

Laura Errecalde,

Sara Kaufman,

Daniela Centrón

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03213-14

Subject(s) - allele , transposable element , plasmid , genetics , biology , klebsiella pneumoniae , aminoglycoside , colistin , homologous recombination , gene , mutation , mutant , antibiotics , escherichia coli

Here, we report that the genetic structure of Tn1331 remained conserved in Argentina from 1989 to 2013 (72 of 73 isolates), with the exception being the plasmid-borne Tn1331-like transposon Tn6238 containing a new aac(6')-Ib-cr allele recovered from a colistin-resistant Klebsiella pneumoniae clinical isolate. A bioinformatic analysis of aac(6')-Ib-like gene cassettes suggests that this new aac(6')-Ib-cr allele emerged through mutation or homologous recombination in the Tn1331 genetic platform. Tn6238 is a novel platform for the dissemination of aminoglycoside and fluoroquinolone resistance determinants.

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