Pyochelin Potentiates the Inhibitory Activity of Gallium on Pseudomonas aeruginosa | Zendy

Emanuela Frangipani | Zendy; Carlo Bonchi | Zendy; Fabrizia Minandri | Zendy; Francesco Imperi | Zendy; Paolo Visca | Zendy

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Pyochelin Potentiates the Inhibitory Activity of Gallium on Pseudomonas aeruginosa

Author(s) -

Emanuela Frangipani,

Carlo Bonchi,

Fabrizia Minandri,

Francesco Imperi,

Paolo Visca

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03154-14

Subject(s) - siderophore , pseudomonas aeruginosa , gallium , minimum inhibitory concentration , antibacterial activity , chemistry , pseudomonadaceae , potency , microbiology and biotechnology , bacteria , pseudomonadales , biological activity , antibacterial agent , in vitro , biochemistry , biology , antibiotics , organic chemistry , genetics , gene

Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon.

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