Open AccessAn Immunocompromised Child with Bloodstream Infection Caused by Two Escherichia coli Strains, One Harboring NDM-5 and the Other Harboring OXA-48-Like Carbapenemase
Author(s) -
M. Earth Hasassri,
Thomas G. Boyce,
Andrew P. Norgan,
Scott A. Cunningham,
Patricio Jeraldo,
Scott J. Weissman,
Robin Patel,
Ritu Banerjee,
Jason M. Pogue,
Keith S. Kaye
Publication year - 2016
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.03118-15
Subject(s) - meropenem , escherichia coli , microbiology and biotechnology , biology , enterobacteriaceae , genotype , bloodstream infection , gene , virology , antibiotic resistance , genetics , antibiotics
We describe a 16-year-old neutropenic patient from the Middle East with bloodstream infection caused by two carbapenemase-producingEscherichia coli isolates that we characterized by whole-genome sequencing. While one displayed meropenem resistance and wasbla NDM positive, the other demonstrated meropenem susceptibility yet harboredbla OXA181 (which encodes abla OXA48 -like enzyme). This report highlights the challenge of laboratory detection ofbla OXA48 -like enzymes and the clinical implications of genotypic resistance detection in carbapenemase-producingEnterobacteriaceae .
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