In Vitro Activities of Eight Antifungal Drugs against 104 Environmental and Clinical Isolates of Aureobasidium pullulans | Zendy

Mohammad Javad Najafzadeh | Zendy; Deanna A. Sutton | Zendy; M. Saradeghi Keisari | Zendy; Hossein Zarrinfar | Zendy; Sybren de Hoog | Zendy; Anuradha Chowdhary | Zendy; Jacques F. Meis | Zendy

Open Access

In Vitro Activities of Eight Antifungal Drugs against 104 Environmental and Clinical Isolates of Aureobasidium pullulans

Author(s) -

Mohammad Javad Najafzadeh,

Deanna A. Sutton,

M. Saradeghi Keisari,

Hossein Zarrinfar,

Sybren de Hoog,

Anuradha Chowdhary,

Jacques F. Meis

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03095-14

Subject(s) - aureobasidium pullulans , itraconazole , microbiology and biotechnology , caspofungin , voriconazole , posaconazole , amphotericin b , micafungin , biology , fungi imperfecti , fluconazole , antifungal , food science , fermentation

Aureobasidium pullulans is an unusual agent of phaeohyphomycosis. The in vitro activities of antifungals against 104 isolates of Aureobasidium pullulans var. pullulans and A. pullulans var. melanigenum revealed low MIC90s of amphotericin B, posaconazole, and itraconazole. However, they were resistant to fluconazole (≥64 μg/ml) and had high MICs of voriconazole, isavuconazole, caspofungin, and micafungin.

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