Initial Assessment of the Molecular Epidemiology of bla NDM-1 in Colombia | Zendy

Laura J. Rojas | Zendy; Meredith S. Wright | Zendy; Elsa De La Cadena | Zendy; Gabriel Motoa | Zendy; Kristine M. Hujer | Zendy; María Virginia Villegas | Zendy; Mark D. Adams | Zendy; Robert A. Bonomo | Zendy

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Initial Assessment of the Molecular Epidemiology of bla _NDM-1 in Colombia

Author(s) -

Laura J. Rojas,

Meredith S. Wright,

Elsa De La Cadena,

Gabriel Motoa,

Kristine M. Hujer,

María Virginia Villegas,

Mark D. Adams,

Robert A. Bonomo

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03072-15

Subject(s) - epidemiology , molecular epidemiology , biology , geography , medicine , genetics , genotype , gene

We report complete genome sequences of fourbla NDM-1 -harboring Gram-negative multidrug-resistant (MDR) isolates from Colombia. Thebla NDM-1 genes were located on 193-kb Inc FIA, 178-kb Inc A/C2, and 47-kb (unknown Inc type) plasmids. Multilocus sequence typing (MLST) revealed that these isolates belong to sequence type 10 (ST10) (Escherichia coli ), ST392 (Klebsiella pneumoniae ), and ST322 and ST464 (Acinetobacter baumannii andAcinetobacter nosocomialis , respectively). Our analysis identified that the Inc A/C2 plasmid inE. coli contained a novel complex transposon (Tn125 and Tn5393 with three copies ofbla NDM-1 ) and a recombination “hot spot” for the acquisition of new resistance determinants.

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