Resistome Analysis of Enterobacter cloacae CY01, an Extensively Drug-Resistant Strain Producing VIM-1 Metallo-β-Lactamase from China | Zendy

Ling Yang | Zendy; Aiwu Wu | Zendy; Danhong Su | Zendy; Yongping Lin | Zendy; Dingqiang Chen | Zendy; YuRong Qiu | Zendy

Open Access

Resistome Analysis of Enterobacter cloacae CY01, an Extensively Drug-Resistant Strain Producing VIM-1 Metallo-β-Lactamase from China

Author(s) -

Ling Yang,

Aiwu Wu,

Danhong Su,

Yongping Lin,

Dingqiang Chen,

YuRong Qiu

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.03060-14

Subject(s) - enterobacter cloacae , plasmid , resistome , cole1 , biology , microbiology and biotechnology , gene , drug resistance , strain (injury) , replicon , genetics , virology , enterobacteriaceae , integron , escherichia coli , anatomy

Resistome analysis of clinical VIM-1-producing Enterobacter cloacae strain CY01 from China revealed the presence of multiple resistance determinants. Two resistance plasmids were identified in CY01. The pCY-VIM plasmid was 14 kb in size and possessed a replicase gene (repA), a gene cluster encoding the partitioning function (parABC), and a carbapenemase gene (blaVIM-1). Another 5.9-kb plasmid, pCY-MdT, with an aac(6')-Ib gene, was very closely related (13 nucleotide differences) to pMdT1, a ColE1 plasmid carrying aac(6')-Ib-cr4.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research